Skip to search formSkip to main contentSkip to account menu
DOI:10.1055/s-0037-1616734 - Corpus ID: 10976556
@article{Versteeg2001ThePE, title={The Pleiotropic Effects of Tissue Factor: a Possible Role for Factor VIIa-induced Intracellular Signalling?}, author={Henri H. Versteeg and Maikel Petrus Peppelenbosch and Arnold Spek}, journal={Thrombosis and Haemostasis}, year={2001}, volume={86}, pages={1353 - 1359}, url={https://api.semanticscholar.org/CorpusID:10976556}}
- H. Versteeg, M. Peppelenbosch, Arnold Spek
- Published in Thrombosis and Haemostasis 1 December 2001
- Biology, Medicine
Tissue factor, a 47 kDa membrane glycoprotein, lies at the basis of the extrinsic pathway of the coagulation cascade, thereby inducing the formation of a blood clot and elicits a variety of intracellular signalling events that may be implicated in these actions.
97 Citations
22
2
97 Citations
- H. VersteegM. PeppelenboschC. Spek
- 2003
Biology, Medicine
Carcinogenesis
It is now understood that the role of TF in angiogenesis is both coagulation-dependent and independent and the recent evidence for this emerging insight will be the subject of this review.
- 78
- PDF
- H. VersteegH. BresserC. SpekD. RichelH. DeventervanS.J.M. Peppelenbosch
- 2003
Biology, Medicine
Journal of thrombosis and haemostasis : JTH
p21Ras activation is instrumental in F VIIa signal transduction and the FVIIa‐dependent activation of p 21Ras involves either PKC or Src‐dependent mechanisms, depending on the cell type investigated.
- B. KocatürkH. Versteeg
- 2012
Biology, Medicine
Thrombosis research
- 35
- Henri Versteeg1 , 2Wolfram Ruf2
- 2006
Medicine, Biology
This review relates the current understanding of direct TF signaling pathways to the emerging roles of TF in (patho)physiology to show the importance of direct or indirect cell signaling in inflammation, tumor growth, and angiogenesis.
- H. Versteeg
- 2004
Biology, Medicine
Seminars in hematology
The role of TF and its ligand FVIIa in inflammation, sepsis, and signal transduction is discussed, and the way in which these processes interact is described.
- 29
- C. EttelaieChao Li N. J. James
- 2007
Medicine
Atherosclerosis
- 21
- A. RoyR. PrasadAnindita BhattacharyaK. DasP. Sen
- 2017
Medicine, Biology
The molecular elucidation of the role of these coagulation factors in cancer-associated thrombosis and metastatic progression has not been understood till date.
- 2
- H. VersteegC. SpekD. RichelM. Peppelenbosch
- 2004
Medicine, Biology
Oncogene
It is proposed that FVIIa-induced cell survival may explain why overexpression of TF is associated with successful metastasis.
- 109
- PDF
- Dick J. RicherS. J. DeventerM. Peppelenbosch
- 2009
Medicine
The results show that the sequence hom*ology between the cytokine class II receptors and TF is reflected in similar downstream signal transduction and the activation of STAT transcription factors provides an obvious link between FVIIa:TF and the associated pro-inflammatory events.
- Manneke BresserJ. DickS. V. DeventerM. Peppelenbosch
- 2009
Biology, Medicine
It is observed that in both BHK and HaCaT cells FVIIa-induced MAP kinase activation correlates with p21Ras activation, and that this p21 ras activation is essential for F VIIa- induced MAP kinases activation.
- 37
- PDF
...
...
77 References
- R. Bach
- 1988
Medicine
The features of TF structure and function which tailor it to the role of initiator of the coagulation cascade are considered and a kinetic model for the molecular mechanism of TF-initiated clotting is reviewed.
- 204
- R. Bach
- 1988
Biology, Medicine
CRC critical reviews in biochemistry
The features of TF structure and function which tailor it to the role of initiator of the coagulation cascade are considered and a kinetic model for the molecular mechanism of TF-initiated clotting is reviewed.
- 155
- E. CamererJ. Røttingen H. Prydz
- 1999
Biology, Medicine
The Journal of Biological Chemistry
Evidence is reported suggesting that protease-activated receptor 2 or a close hom*ologue may be a necessary but not sufficient component of this particular signal transduction pathway in coagulation factors VIIa and Xa.
- 193
- PDF
- M. CunninghamP. RomasP. HutchinsonS. HoldsworthP. Tipping
- 1999
Medicine, Biology
Blood
These studies provide the first demonstration of a direct proinflammatory role for TF acting as a cell-signaling receptor, and demonstrate that, in addition to its role in activation of coagulation, TF can directly augment macrophage activation.
- 123
- P. CarmelietN. Mackman D. Collen
- 1996
Biology, Medicine
Nature
It is reported that inactivation of the tissue factor gene (TF) results in abnormal circulation from yolk sac to embryo beyond embryonic day 8.5, leading to embryo wasting and death, implying that tissue factor has a role in bloodvessel development.
- 741
- Y. MullerM. UltschR. KelleyA. D. de Vos
- 1994
Medicine
Biochemistry
Alanine-scanning mutagenesis has identified tissue factor residues important for factor VIIa binding on the opposite side of the molecule compared to the growth hormone receptor, with the binding determinants residing on beta-strands rather than on loops.
- 140
- K. HarlosD. M. Martin C. Boys
- 1994
Medicine, Biology
Nature
The ocrystal structure of the extracellular region of tissue factor is determined and this is the first reported structure of a representative of the class 2 cytokine receptor family, which also includes interferon-α, interferons-γ and interleukin-10 receptors.
- 211
- O. ThastrupG. Hagel L. Petersen
- 2000
Medicine
Thrombosis and Haemostasis
The data suggest that the intracellular response was not induced by an autocrine release of a soluble mediator to the medium, and is distinctly different from that induced by trypsin, thrombin and FXa not involving any of the known PARs.
- 68
- M. TaubmanJ. MarmurClaire-Lise RosenfieldArabinda GuhaSteven NichtbergerYale Nemerson
- 1993
Medicine, Biology
The Journal of clinical investigation
It is reported that TF mRNA and protein are rapidly and markedly induced in early and late passaged vascular smooth muscle cells (VSMC) by growth factors, vasoactive agonists, and a clotting factor (alpha-thrombin) and the possibility that protein kinase C activation may not be necessary for TF mRNA induction in VSMC.
- 176
- Highly Influential
- PDF
- G. Broze
- 1995
Medicine
Annual review of medicine
The properties of this rediscovered inhibitor appear, at least in part, to explain the clinical requirement for both the extrinsic and intrinsic pathways of the cascade and waterfall theories of blood clotting and have led to a reformulation of the coagulation mechanism.
- 309
...
...
Related Papers
Showing 1 through 3 of 0 Related Papers